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ARTIGOS RECENTES - TRIBUTO 90 ANOS PROF. RAIMUNDO BRAZ FILHO


Artigo

Comparative study of the chemical composition of amapa latex from Parahancornia Amapa and Brosimum parinarioides BY HPLC-UV-DAD

Rita Cynara de Oliveira SallesI,II,*; Sergio Massayoshi NunomuraII; Norberto Peporine LopesIII;
Rita de Cássia Saraiva NunomuraI,*

Amapa latex is a traditional medicine in the Amazon and is commercialized from two plant species Parahancornia amapa and Brosimum parinarioides. We report the isolation of the main compounds from both species and compared the chromatographic profiles by high-performance liquid chromatography (HPLC).

http://dx.doi.org/10.21577/0100-4042.20250187

Publicado online: julho 29, 2025
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Total access: 70

Detecção de flavonoides com propriedades tripanocida e antioxidante nas folhas de Senna multijuga (Fabaceae)

Cássia G. MagalhãesI,II,*; Ana Letícia P. dos SantosII; Marcelino S. do RosárioII; Elton KazmierczakI; André V. BassaniI;
Christiana A. PessoaI; Jorge IarmulIII; Iriane EgerIII; Vanderlan S. BolzaniII

A diagram linking the molecular networking of extracts from Senna multijuga obtained from Global Natural Product Social Molecular Networking (GNPS) platform and the antioxidant and tripanocidal potential of this species is presented in this Graphical Abstract.

http://dx.doi.org/10.21577/0100-4042.20250186

Publicado online: julho 29, 2025
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Total access: 68

Chemical and biological investigation of Cattleya nobilior Rchb. F. (Orchidaceae): targeting on phenanthrene and stilbenoid derivatives

Caroline de Moura CostaI,#; Katyuce Souza FariasI,#; Izadora BonfimI,#; Heron F. V. TorquatoII; Samara Requena NocchiI;
Laís Azevedo RodriguesI; Júlio Mentha AlmeidaIII; Flávio Macedo AlvesIV; Alda Maria Teixeira FerreiraIII; Helori Vanni DomingosV;
Edgar J. Paredes-GameroII; Leticia V. Costa-LotufoV; Carlos Alexandre CarolloI; Denise Brentan SilvaI,*

The graphical abstract depicts the solvent extraction of Cattleya nobilior to evaluate cytotoxic and anti-Trypanosoma cruzi activities. Metabolomics analysis linked chemical composition to bioactivity, revealing promising pharmacological potential.

http://dx.doi.org/10.21577/0100-4042.20250185

Publicado online: julho 29, 2025
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Total access: 75

In silico and in vitro activity of friedelin N-derivatives against promastigote forms of Leishmania amazonensis

Mauro Lúcio Gonçalves de OliveiraI; Lucienir Pains DuarteI; Grácia Divina de FátimaI; Silvia Ribeiro de SouzaII;
Misléia Rodrigues de Aguiar GomesII; Sidney Augusto Vieira-FilhoI,III; Vera Lucia de AlmeidaI,IV; Júlio César Dias LopesI,*

This study investigates N-derivatives of friedelan-3-one from Maytenus gonoclada, employing the NEQUIM Active-IT bioactivity prediction tool and experimentally validating their in vitro activity against Leishmania amazonensis, thereby revealing potential therapeutic applications.

http://dx.doi.org/10.21577/0100-4042.20250184

Publicado online: julho 22, 2025
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Total access: 127

Metabolic diversity of zoantharians collected at brazilian oceanic islands

Bianca Del B. SahmI,II,#; Ana C. ZanattaII,#; Francisco da Chagas L. PintoIII; Otília D. L. PessoaIII; Diego V. WilkeIV; Paula C. JimenezV; Norberto P. LopesII; Tito M. C. LotufoVI; Letícia V. Costa-LotufoI,*

The metabolic fingerprinting of Palythoa caribaeorum, Palythoa variabilis and Zoanthus spp. collected at different Brazilian oceanic islands showed core species-specific metabolites similar to those of continental zoantharians, and a dynamic fraction of an environment-driven chemodiversity.

http://dx.doi.org/10.21577/0100-4042.20250178

Publicado online: julho 22, 2025
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Total access: 213

Chemical composition and measuring the distribution of haemanthidine by MALDI-TOF MS imaging from Crinum scabrum leaves

Jennifer B. PardoI; Amanda E. FeuI; Faviola A. VigamonteII; Warley de S. BorgesI,*

Extraction, isolation and detection of haemanthidine in the Crinum scabrum leaves.

http://dx.doi.org/10.21577/0100-4042.20250183

Publicado online: julho 21, 2025
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Total access: 117

Diterpenoids from the roots of Annona vepretorum Mart. (Annonaceae)

Ana L. M. SouzaI; Jéssica F. AuzierII; Lívia M. DutraI; Victoria L. A. SantosIII; Emmanoel V. CostaII; Jackson R. G. S. AlmeidaI,*

Five substances belonging to the terpenoid class were isolated from the roots of Annona vepretorum Mart. The five substances are characterized by the presence of the kaurene and kaurane diterpenes skeleton. The compound 17-nor-kaur-16-one (2) is being reported for the first time in the Annonaceae family.

http://dx.doi.org/10.21577/0100-4042.20250182

Publicado online: julho 21, 2025
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Total access: 120

Análise quimiossistemática da família myristicaceae: a via mista (acetato/chiquimato)

Raquel M. de S. N. SampaioI,*; Adriana L. de SousaII; Rodrigo B. B. FeitozaI; Rodrigo R. de OliveiraI; Maria Raquel G. VegaI

The genera of the Myristicaceae family that have special mixed pathway metabolites are Horsfieldia, Iryanthera, Knema, Myristica, Pycnanthus and Virola.

http://dx.doi.org/10.21577/0100-4042.20250181

Publicado online: julho 21, 2025
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Total access: 129

Otimização de extração de compostos fenólicos das folhas de Lippia alba (Mill.) N. E. Brown por ultrassom e comparação com técnicas convencionais

Raphael A. de JesusI; Julio M. A. OliveiraI; José M. da SilvaI; Wenes R. da SilvaI; Alberto Wisniewski JrI; José C. F. S. FilhoII; Arie F. BlankII; Daniel A. de SouzaIII; Elma R. S. A. WarthaIII; Paulo C. L. NogueiraI; Valéria R. S. MoraesI,*

Optimization of extraction of phenolic compounds from Lippia alba (Mill.) N. E. Brown leaves by ultrasound and comparison with conventional techniques.

http://dx.doi.org/10.21577/0100-4042.20250173

Publicado online: julho 7, 2025
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Total access: 220

Exploring the antioxidant activity of Eugenia uniflora L. extracts: a comparative approach by different techniques

Vinicius Monteiro Schaffka; Cássia Gonçalves Magalhães*; Romaiana Picada Pereira

The graphical abstract shows a diagram linking Eugenia uniflora L. leaf extracts, antioxidant activity, and analytical techniques (total phenolic content (TPC), total flavonoid content (TFC), gas chromatography-mass spectrometry (GC-MS), and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS)) used in this study as well as the molecular structures of the compounds found in this species.

http://dx.doi.org/10.21577/0100-4042.20250168

Publicado online: julho 1, 2025
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Total access: 207

Bixa orellana lipids as a source of geranylgeraniol: extraction techniques and characterization

Miguel A. Martinez Gutierrez; Igor F. P. da Silva; Henrique F. Goulart; Antônio E. G. Santana*

Obtaining oil from urucum seeds by ultrasound-assisted extraction, Soxhlet, and steam distillation methods, characterization, and quantification.

http://dx.doi.org/10.21577/0100-4042.20250165

Publicado online: junho 25, 2025
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Total access: 224

A new prenylated guaiane from the brown seaweed Dictyota mertensii

Neilyane de Paula FernandesI; Fábio do Nascimento ÁvilaI; Késya Amanda D. RochaI; Pedro B. de Mâcedo CarneiroII; Greyce L. SasaharaIII; Flavia A. SantosIV; Edilberto R. SilveiraI; Otília Deusdenia L. PessoaI,*

The chemical investigation of the ethyl acetate extract from the brown seaweed Dictyota mertensii led to the isolation of prenylated guaiane and dolabellane diterpenes.

http://dx.doi.org/10.21577/0100-4042.20250164

Publicado online: junho 25, 2025
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Total access: 202

Amides isolated from the leaves of Piper tuberculatum Jacq. (Piperaceae) with acetylcholinesterase inhibition and larvicidal activity against Aedes aegypti

Brenda R. C. LeocadioI,II,*; Taynara S. ValeIII; Felipe M. A. da SilvaI,II; João V. C. O. SantosII; Sergio M. NunomuraIV; André C. de OliveiraV; Ingrity S. C. SáVI; Rosemary A. RoqueV; Ana Paula A. CastroI,II; Magno P. MunizIV; Rita C. S. NunomuraI,II,III*

cis-Piplartine, piplartine and 4,5-dihydropiperlongumine isolated from leaves of Piper tuberculatum were active against Aedes aegypti larvae and have acetylcholinesterase (AChE) inhibitory activity.

http://dx.doi.org/10.21577/0100-4042.20250162

Publicado online: junho 17, 2025
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Total access: 230

LC-MS/MS based dereplication of isoquinoline-derived alkaloids from the trunk bark of Unonopsis rufescens (Baill.) R.E.Fr. (Annonaceae)

Lucas Antônio F. de AlmeidaI,II; Felipe Moura A. da SilvaI,II,*; Bruna Ribeiro de LimaII,III; Aline Bastos B. de SousaII; Francinaldo A. da Silva FilhoII; Brenda R. C. LeocadioI,II; Ana Paula A. CastroI,II; Rebeca dos S. FrançaI,II; Hector H. F. KoolenIV; Afonso D. L. de SouzaI,II,III; Maria Lúcia B. PinheiroII,III,*

Pallidine and other isoquinoline-derived alkaloids were tentatively identified in the trunk bark of U. rufescens through liquid chromatography coupled to tandem mass spectrometry analysis (LC-MS/MS) and fragmentation pattern analysis.

http://dx.doi.org/10.21577/0100-4042.20250159

Publicado online: junho 17, 2025
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Total access: 212

Peltogynoids from Peltogyne catingae ducke and their antifungal potential against Sporothrix spp.

Davi S. OliveiraI; Priscila B. A. de SouzaI; Luiz Henrique K. Queiroz-JuniorII; Denise O. ScoarisIII; Luana P. da SilvaIII; Claudete C. do NascimentoIV; Maria da Paz LimaIV,*

The modified flavonoids known as peltogynoids extracted from the wood residues of Peltogyne catingae Ducke ("roxinho") presented antifungal properties against Sporothrix schenckii and S. brasiliensis that cause feline sporotrichosis.

http://dx.doi.org/10.21577/0100-4042.20250158

Publicado online: junho 16, 2025
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Total access: 268

1-Indanone derivatives: a novel one-pot approach to imides via beckmann-like rearrangement and theoretical insights into their interactions with ache enzyme

Thiago R. F. BastosI; Telma Leda G. de LemosI; Raimundo Braz FilhoII,III; Aluísio Marques da FonsecaIV;
Francisco J. Queiroz MonteI,*

Novel imides were synthesized from (E)-2,3-dihydro-1H-inden-1-one oxime via Beckmann-like rearrangement with nucleophilic catalysts. Molecular docking indicated that derivatives 5i, 5g, and 5h showed promising acetylcholinesterase inhibition compared to galantamine.

http://dx.doi.org/10.21577/0100-4042.20250154

Publicado online: junho 11, 2025
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Total access: 222

Antimicrobial activity of compounds isolated from mangrove-derived endophytic fungus Actinomucor elegan against Xanthomonas axonopodis pv. passiflorae

Kathia Raquel Murillo PadillaI; Rayanne Priscila Vieira da ConceiçãoI; Gisele da Costa RamosI; Luana Cardoso de OliveiraII,
José Edson de Sousa SiqueiraI; Mayra Suelen da Silva PinheiroIII; Patrícia Santana Barbosa MarinhoI,;
Andrey Moacir do Rosario MarinhoI,II,*

Tyrosol derivative compounds isolated from Actinomucor elegan fungus show good antimicrobial activity against  Xanthomonas bacteria which causes bacterial spots in passion fruit.

http://dx.doi.org/10.21577/0100-4042.20250153

Publicado online: junho 10, 2025
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Total access: 261

Glicosídeos esteroidais de Solanum jabrense Agra & M.Nee

Anauara Lima e SilvaI; Thiago A. M. BritoI; Maria de Fátima AgraII; Marcelo S. da SilvaI; Josean F. TavaresI,*

Saponins and glycosylated steroidal alkaloids were isolated from the hydroalcoholic extract of aerial parts of Solanum jabrense Agra & M.Nee, identified and characterized by nuclear magnetic resonance (NMR), infrared spectroscopy (IR), mass spectrometry (MS) and optical rotation.

http://dx.doi.org/10.21577/0100-4042.20250151

Publicado online: junho 10, 2025
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Total access: 228

Regioselective and chemoselective biocatalytic reduction of α,β,γ,δ-unsaturated ketones by marine-derived fungus Penicillium citrinum CBMAI 1186

Pedro H. DamadaI,*; Pedro H. O. SantiagoII; Javier EllenaII; André L. M. PortoI

The graphic shows Penicillium citrinum CBMAI 1186 reducing α,β-unsaturated ketones to γ,δ-unsaturated ketones at 32 ºC and 135 rpm. This demonstrates the regioselective and chemoselective efficiency of the strain, highlighting its potential as a biocatalyst.

http://dx.doi.org/10.21577/0100-4042.20250149

Publicado online: junho 3, 2025
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Total access: 260

Stereoselective oxidative coupling of methyl trans-ferulate to (±)-trans-dehydrodiferulate dimethyl ester by Trametes versicolor FC: an enantioselective green approach

Eliane O. SilvaI,*; Herbert J. DiasII,III; Anderson R. M. OliveiraIII; Antônio E. M. CrottiIII

Methyl trans-ferulate was converted into the dihydrobenzofuran neolignan trans-dehydroferulate dimethyl ester with good enantioselectivity using an advantageous approach based on Trametes versicolor FC.

http://dx.doi.org/10.21577/0100-4042.20250147

Publicado online: maio 30, 2025
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Total access: 281

Hirtinol A: a new limonoid from the seeds of Trichilia hirta Linneaus (Meliaceae)

Renata Rodrigues da Silva RobainaI,*; Gabriela DinisII; Lucas Silva AbreuII; Raimundo Braz-FilhoI,III; Ivo José Curcino VieiraI

The phytochemical study of Trichilia hirta Linneaus (Meliaceae) seeds resulted in the isolation and identification of a new limonoid named Hirtinol A, in addition to a mixture of 21α-melianone and 21β-melianone, and the glycoside schumaniofioside A.

http://dx.doi.org/10.21577/0100-4042.20250146

Publicado online: maio 21, 2025
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Total access: 295

Fenilpropanoides com ação anti-Trypanosoma cruzi isolados das folhas de Piper crassinervium (Piperaceae)

Nathalia F. QuintilianoI,II; Sávio R. SoaresII; Miriam UemiI; Guilherme M. AntarIII; Patricia SartorelliII; Andre G. TemponeIV;
João Henrique G. LagoI,*

Bioactive hexane extract from leaves of Piper crassinervium was subjected to a bioactivity-guided fractionation to afford five metabolites (1-5). Compound 5 is previously undescribed while compounds 1, 2 and 4 are being described for the first time in P. crassinervium. Compounds 1-5 were evaluated against trypomastigote forms of parasite Trypanosoma cruzi whereas their toxicity was evaluated against NCTC cells.

http://dx.doi.org/10.21577/0100-4042.20250145

Publicado online: maio 21, 2025
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Total access: 305

Chemical constituents from the leaves of Eriodictyon californicum (Hook. & Arn.) Torr. (Boraginaceae)

Brenda K. M. SousaI; Talita L. N. GonçalvesI; Lívia M. DutraI; Victória L. A. SantosII; Emmanoel Vilaça CostaIII;
Agnaldo R. M. ChavesIV, José M. PintoIV, Marcelo F. R. SilvaV; Yuri M. NascimentoV; Josean F. TavaresV; Marcelo S. SilvaV;
Jackson R. G. S. AlmeidaI,*

Seven compounds, belonging to the flavonoid, phenylpropanoid and chromone classes, were isolated from the leaves of Eriodictyon californicum. Among the isolated compounds, ethyl cinnamate (6) and 5-hydroxy-7-methoxychromone (7) are being reported for the first time in E. californicum and in the Boraginaceae family.

http://dx.doi.org/10.21577/0100-4042.20250140

Publicado online: maio 12, 2025
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Total access: 332

Chemical composition, antioxidant potential, and cholinesterase inhibitory activity of essential oils from three Thunbergia species growing wild in northeast Brazil

Alice M. S. de Almeida; Tchiara M. A. Tenório; Lucas V. B. Rodrigues; Carolina A. de Araujo; Claudio A. G. da Camara*;
Marcilio M. de Moraes

The analysis of essential oils from three Thunbergia species revealed differences in their chemical profiles, but all contained sesquiterpenes as the predominant compounds. The oil from T. erecta demonstrated the highest efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid), AChE (acetylcholinesterase), and BuChE (butyrylcholinesterase) assays.

http://dx.doi.org/10.21577/0100-4042.20250139

Publicado online: maio 9, 2025
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Total access: 336

Fragmentation of deprotonated plumeran indole alkaloids by electrospray ionization tandem mass spectrometry

Yan R. RoblesI; Ricardo VessecchiI; Ivo J. C. VieiraII; Raimundo Braz-FilhoII,III,#; Antonio E. M. CrottiI,*

The fragmentation of deprotonated aspidospermine, aspidocarpine, demethoxypalosine, and aspidolimine was investigated in this work using negative electrospray ionization tandem mass spectrometry.

http://dx.doi.org/10.21577/0100-4042.20250138

Publicado online: maio 9, 2025
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Total access: 260

A new alkaloid isolated from Tabernaemontana hystrix Steud. (Apocynaceae) and the antiproliferative potential of the root bark against human cervical cancer (HeLa)

Thalya S. R. NogueiraI,*; Thiago C. SardouII; Julio Cesar Thurler JúniorII; Gabriela DinisIII; Vinícius D'avila B. PascoalII;
Lucas S. AbreuIII; Raimundo Braz FilhoI,IV; Aislan C. R. F. PascoalII; Ivo José C. VieiraI

Tabernaemontana hystrix (Apocynaceae) root bark showed antiproliferative potential against the HeLa cell line. Six alkaloids were isolated from EtOAc or BuOH fractions. Compounds 3 and 4 are being reported for the first time in the species, and compound 6 is new in the literature.

http://dx.doi.org/10.21577/0100-4042.20250137

Publicado online: maio 6, 2025
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Total access: 358

Phytochemical study from the aerial parts of Pavonia malacophylla (Malvaceae) and evaluation of its antimicrobial potential

Janderson Barbosa Leite de AlbuquerqueI; Otemberg Souza ChavesI; Wallace Amorim Machado de QueirozI;
Bárbara Fernandes Araújo RodriguesII; Diégina Araújo FernandesIII; Fábio Correia SampaioIV; Maria de Fátima AgraV; Maria de Fátima Vanderlei de SouzaI,II,*

A phytochemical investigation of the aerial parts of Pavonia malacophylla resulted in the isolation and identification of eighteen compounds, revealing antimicrobial potential in its extract, fractions and isolated compounds.

http://dx.doi.org/10.21577/0100-4042.20250134

Publicado online: maio 5, 2025
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Total access: 284


Revisão

Constituintes químicos e atividades biológicas de Remijia DC. (Rubiaceae): uma revisão

Fábio G. de Souza; Gabriel S. Crispim; Luana da C. Moreira; Cecilia V. Nunez*

Main databases used to search for articles about Remijia, and some of their biological activities and chemical substances.

http://dx.doi.org/10.21577/0100-4042.20250120

Publicado online: abril 3, 2025
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Total access: 399


Nota Técnica

Collision-induced dissociation in ESI-MS/MS of caramboxin isolated from Averrhoa carambola: computational and mass spectrometry studies

Ricardo VessecchiI; Pâmela R. R. PereiraII; Leonardo Gobbo-NetoII; Norberto Garcia-CairascoIII; Norberto Peporine LopesII,*

Fragmentation from electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of caramboxin, a natural toxin, was explored using computational chemistry.

http://dx.doi.org/10.21577/0100-4042.20250160

Publicado online: junho 17, 2025
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Total access: 190


Educação

A reação de substituição eletrofílica aromática e os efeitos dos grupos nitroso e flúor: correção de imprecisões em livros texto

Igor SandeI; Leonardo AntonelliI; Matheus Almeida Ramos de JesusI; Silvio CunhaI,II,*

The effects of nitroso and fluorine groups in electrophilic aromatic substitution lack consensus across literature and textbooks. Beneath this apparent inconsistency lies a deeper layer of inherent details governing their effects on reactivity, which we unveil in this study.

http://dx.doi.org/10.21577/0100-4042.20250188

Publicado online: julho 30, 2025
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Total access: 94

On-line version ISSN 1678-7064 Printed version ISSN 0100-4042
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