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9:04, qui jun 5

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ARTIGOS RECENTES - TRIBUTO 90 ANOS PROF. RAIMUNDO BRAZ FILHO


Artigo

REGIOSELECTIVE AND CHEMOSELECTIVE BIOCATALYTIC REDUCTION OF α,β,γ,δ-UNSATURATED KETONES BY MARINE-DERIVED FUNGUS Penicillium citrinum CBMAI 1186

Pedro H. Damada; Pedro H. O. Santiago; Javier Ellena; André L. M. Porto

The graphic shows Penicillium citrinum CBMAI 1186 reducing α,β-unsaturated ketones to γ,δ-unsaturated ketones at 32 ºC and 135 rpm. This demonstrates the regioselective and chemoselective efficiency of the strain, highlighting its potential as a biocatalyst.

http://dx.doi.org/10.21577/0100-4042.20250149

Publicado online: junho 3, 2025
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Total access: 24

Stereoselective oxidative coupling of methyl trans-ferulate to (±)-trans-dehydrodiferulate dimethyl ester by Trametes versicolor FC: an enantioselective green approach

Eliane O. SilvaI,*; Herbert J. DiasII,III; Anderson R. M. OliveiraIII; Antônio E. M. CrottiIII

Methyl trans-ferulate was converted into the dihydrobenzofuran neolignan trans-dehydroferulate dimethyl ester with good enantioselectivity using an advantageous approach based on Trametes versicolor FC.

http://dx.doi.org/10.21577/0100-4042.20250147

Publicado online: maio 30, 2025
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Total access: 52

Hirtinol A: a new limonoid from the seeds of Trichilia hirta Linneaus (Meliaceae)

Renata Rodrigues da Silva RobainaI,*; Gabriela DinisII; Lucas Silva AbreuII; Raimundo Braz-FilhoI,III; Ivo José Curcino VieiraI

The phytochemical study of Trichilia hirta Linneaus (Meliaceae) seeds resulted in the isolation and identification of a new limonoid named Hirtinol A, in addition to a mixture of 21α-melianone and 21β-melianone, and the glycoside schumaniofioside A.

http://dx.doi.org/10.21577/0100-4042.20250146

Publicado online: maio 21, 2025
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Total access: 94

Fenilpropanoides com ação anti-Trypanosoma cruzi isolados das folhas de Piper crassinervium (Piperaceae)

Nathalia F. QuintilianoI,II; Sávio R. SoaresII; Miriam UemiI; Guilherme M. AntarIII; Patricia SartorelliII; Andre G. TemponeIV;
João Henrique G. LagoI,*

Bioactive hexane extract from leaves of Piper crassinervium was subjected to a bioactivity-guided fractionation to afford five metabolites (1-5). Compound 5 is previously undescribed while compounds 1, 2 and 4 are being described for the first time in P. crassinervium. Compounds 1-5 were evaluated against trypomastigote forms of parasite Trypanosoma cruzi whereas their toxicity was evaluated against NCTC cells.

http://dx.doi.org/10.21577/0100-4042.20250145

Publicado online: maio 21, 2025
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Total access: 81

Chemical constituents from the leaves of Eriodictyon californicum (Hook. & Arn.) Torr. (Boraginaceae)

Brenda K. M. SousaI; Talita L. N. GonçalvesI; Lívia M. DutraI; Victória L. A. SantosII; Emmanoel Vilaça CostaIII;
Agnaldo R. M. ChavesIV, José M. PintoIV, Marcelo F. R. SilvaV; Yuri M. NascimentoV; Josean F. TavaresV; Marcelo S. SilvaV;
Jackson R. G. S. AlmeidaI,*

Seven compounds, belonging to the flavonoid, phenylpropanoid and chromone classes, were isolated from the leaves of Eriodictyon californicum. Among the isolated compounds, ethyl cinnamate (6) and 5-hydroxy-7-methoxychromone (7) are being reported for the first time in E. californicum and in the Boraginaceae family.

http://dx.doi.org/10.21577/0100-4042.20250140

Publicado online: maio 12, 2025
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Total access: 111

Chemical composition, antioxidant potential, and cholinesterase inhibitory activity of essential oils from three Thunbergia species growing wild in northeast Brazil

Alice M. S. de Almeida; Tchiara M. A. Tenório; Lucas V. B. Rodrigues; Carolina A. de Araujo; Claudio A. G. da Camara*;
Marcilio M. de Moraes

The analysis of essential oils from three Thunbergia species revealed differences in their chemical profiles, but all contained sesquiterpenes as the predominant compounds. The oil from T. erecta demonstrated the highest efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid), AChE (acetylcholinesterase), and BuChE (butyrylcholinesterase) assays.

http://dx.doi.org/10.21577/0100-4042.20250139

Publicado online: maio 9, 2025
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Total access: 116

Fragmentation of deprotonated plumeran indole alkaloids by electrospray ionization tandem mass spectrometry

Yan R. RoblesI; Ricardo VessecchiI; Ivo J. C. VieiraII; Raimundo Braz-FilhoII,III,#; Antonio E. M. CrottiI,*

The fragmentation of deprotonated aspidospermine, aspidocarpine, demethoxypalosine, and aspidolimine was investigated in this work using negative electrospray ionization tandem mass spectrometry.

http://dx.doi.org/10.21577/0100-4042.20250138

Publicado online: maio 9, 2025
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Total access: 101

A new alkaloid isolated from Tabernaemontana hystrix Steud. (Apocynaceae) and the antiproliferative potential of the root bark against human cervical cancer (HeLa)

Thalya S. R. NogueiraI,*; Thiago C. SardouII; Julio Cesar Thurler JúniorII; Gabriela DinisIII; Vinícius D'avila B. PascoalII;
Lucas S. AbreuIII; Raimundo Braz FilhoI,IV; Aislan C. R. F. PascoalII; Ivo José C. VieiraI

Tabernaemontana hystrix (Apocynaceae) root bark showed antiproliferative potential against the HeLa cell line. Six alkaloids were isolated from EtOAc or BuOH fractions. Compounds 3 and 4 are being reported for the first time in the species, and compound 6 is new in the literature.

http://dx.doi.org/10.21577/0100-4042.20250137

Publicado online: maio 6, 2025
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Total access: 155

Phytochemical study from the aerial parts of Pavonia malacophylla (Malvaceae) and evaluation of its antimicrobial potential

Janderson Barbosa Leite de AlbuquerqueI; Otemberg Souza ChavesI; Wallace Amorim Machado de QueirozI;
Bárbara Fernandes Araújo RodriguesII; Diégina Araújo FernandesIII; Fábio Correia SampaioIV; Maria de Fátima AgraV; Maria de Fátima Vanderlei de SouzaI,II,*

A phytochemical investigation of the aerial parts of Pavonia malacophylla resulted in the isolation and identification of eighteen compounds, revealing antimicrobial potential in its extract, fractions and isolated compounds.

http://dx.doi.org/10.21577/0100-4042.20250134

Publicado online: maio 5, 2025
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Total access: 136


Revisão

Constituintes químicos e atividades biológicas de Remijia DC. (Rubiaceae): uma revisão

Fábio G. de Souza; Gabriel S. Crispim; Luana da C. Moreira; Cecilia V. Nunez*

Main databases used to search for articles about Remijia, and some of their biological activities and chemical substances.

http://dx.doi.org/10.21577/0100-4042.20250120

Publicado online: abril 3, 2025
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Total access: 228

On-line version ISSN 1678-7064 Printed version ISSN 0100-4042
Química Nova
Publicações da Sociedade Brasileira de Química
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