JBCS



12:38, seg nov 4

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EDIÇÃO ATUAL vol. 46, No. 4, 2023



Artigo de Capa
Quim. Nova 2023, 46(4), 351-361

Intelligent delivery of antitumor drugs mediated by polymeric nanomicelles: a review

Raquel dos Santos MartinsI; Adriana Pereira DuarteII; Fernando CotinguibaI,*

The image illustrates the targeting capacity of the ligands present on the surface of the nanocarriers and their conformational change caused by the specific chemical environment of the tumor environment, facilitating their introduction into the intracellular environment.

http://dx.doi.org/10.21577/0100-4042.20230011

Publicado online: janeiro 12, 2023
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Total access: 842

Artigo de Contra Capa
Quim. Nova 2023, 46(4), 381-389

Planejamento de fármacos contra COVID-19: uma experiência de ensino remoto de química farmacêutica

Rhanna Victória Amaral da Silva*; Larissa Magno Monteiro; Carlos Henrique Lamego Guimarães Thomaz Branco; Fernanda Guilhon-Simplicio

Virtual screening is a very important tool in Medicinal Chemistry and aims to optimize drug design and development. Thus, molecular docking is an alternative for the search for new bioactive molecules against the SARS-CoV-2.

http://dx.doi.org/10.21577/0100-4042.20230020

Publicado online: fevereiro 3, 2023
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Total access: 1051

Artigo Quim. Nova 2023, 46(4), 307-318

 

Investigação da atividade eletroquímica de liga Al-Cu-Li após processo de soldagem por fricção e mistura

Rejane Maria P. da SilvaI; Mariana X. MilagreI; João Victor de S. AraujoI,*; Oscar Mauricio P. RamirezII; Caruline de Souza C. MachadoI; Renato A. AntunesIII; Isolda CostaI


Local electrochemical activity of the zones affected by Friction Stir Welding (FSW) of an Al-Cu-Li alloy.

http://dx.doi.org/10.21577/0100-4042.20230014

Publicado online: janeiro 20, 2023
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Total access: 572

Quim. Nova 2023, 46(4), 319-328

 

Aromaticity of aza aromatic molecules: prediction from hückel theory with modified parameters

Inge M. SutjahjaI,*; Yuanita P. D. SudarsoII; Shofi Dhiya 'UlhaqI; Erik Bekti YutomoI


Modified Hückel parameters are proposed for acridine and phenazine. The geometric-based aromatic index is calculated to study the aromaticity of the two non-equivalent rings. The bond energies of the bond lengths are calculated and compared with the experimental heats of formation.

http://dx.doi.org/10.21577/0100-4042.20230017

Publicado online: janeiro 27, 2023
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Total access: 528

Quim. Nova 2023, 46(4), 329-335

 

Quantitative and qualitative characterization of the granulometry of an inceptisol

Janaina SchadosinI; Sérgio Costa SaabII,*; André Maurício BrinattiII; Luiz Fernando PiresII


Quantitative and qualitative characterization of the granulometry of a soil and use of dynamic propagation (DLS) aiming to assess the quality of the dimension of the clay fraction.

http://dx.doi.org/10.21577/0100-4042.20230018

Publicado online: janeiro 27, 2023
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Total access: 620

Quim. Nova 2023, 46(4), 336-342

 

Síntese, caracterização de uma base de schiff de quitosana e complexos de cobre utilizadas como eletrodo modificado

Ana C. F. de B. Pontes*; Talita P. de A. Pontes; Nayara G. S. Cavalcante; Francimar Lopes de Sousa Júnior; Francisco Ordelei N. da Silva; Daniel de L. Pontes


The present study carried out the synthesis and characterization of a coordination compound obtained from the reaction of formation of the Shiff base (chitosan/ortho-vanillin) with copper, aiming at a possible application in the identification of nitrite.

http://dx.doi.org/10.21577/0100-4042.20230019

Publicado online: janeiro 27, 2023
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Quim. Nova 2023, 46(4), 343-350

 

Stable isotopes of oxygen and hydrogen in water: analytical method evaluation and the determination of δ18O and δ2h on a control sample

André Abreu MartinsI,II,*; Edinei KoesterIII; Leandro Rufino RosalinoIV; Ronaldo BernardoV; Felipe Padilha LeitzkeII,VI


The graphical abstract shows the δ18O and δ2H data acquired on a reference water sample at different ambient temperature conditions, using the equilibrium method. At 20 °C, analyses performed at the LGI control sample presented satisfactory repeatability and reproducibility.

http://dx.doi.org/10.21577/0100-4042.20230021

Publicado online: fevereiro 10, 2023
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Total access: 662

Revisão Quim. Nova 2023, 46(4), 362-374

 

Nanopartículas de sílica (NPSiO2) utilizadas para o tratamento de distúrbios associados ao sistema nervoso central (SNC)

João Vitor Raupp de OliveiraI; Jussânia de Almeida GnoattoII; Tanira Alessandra Silveira AguirreI,III,*


Silica nanoparticles are reliable systems with advantageous physicochemical properties to the application as drug delivery systems for the treatment of neurological disorders.

http://dx.doi.org/10.21577/0100-4042.20230015

Publicado online: janeiro 24, 2023
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Total access: 600

Nota Técnica Quim. Nova 2023, 46(4), 375-380

 

Validation of an analytical method for the determination of fatty acids in sheep blood serum samples

Matheus Julien Ferreira BazzanaI; Juliana GarciaI; Gabriela Françozo VilelaI; Cleber Nogueira BorgesI; Letícia Rodrigues FariaII; Nadja Gomes AlvesII; Adelir Aparecida SaczkI,*


Using a chemometric mixture design and a miniaturized sample preparation technique, LA and SA were extracted from sheep blood serum samples. After an esterification process, the extract was analyzed, and the developed method was validated.

http://dx.doi.org/10.21577/0100-4042.20230009

Publicado online: janeiro 12, 2023
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Assuntos Gerais Quim. Nova 2023, 46(4), 390-404

 

Questões regulatórias sobre a desinfecção da água e o impacto da geração de DBPs na qualidade da água tratada

Beatriz De Caroli Vizioli; Cassiana Carolina Montagner*


Urban water cycle with DBP generation in DWTPs (drinking water treatment plants) and WWTPs (wastewater treatment plants), and the trade-off between the microbiological and chemical risks.

http://dx.doi.org/10.21577/0100-4042.20230029

Publicado online: março 2, 2023
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Total access: 629

On-line version ISSN 1678-7064 Printed version ISSN 0100-4042
Química Nova
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