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vol. 48, No. , 2025

Special Issues



Revisão Quim. Nova 2025, 48(), e-20250120, 1-8

 

Constituintes químicos e atividades biológicas de Remijia DC. (Rubiaceae): uma revisão

Fábio G. de Souza; Gabriel S. Crispim; Luana da C. Moreira; Cecilia V. Nunez*


Main databases used to search for articles about Remijia, and some of their biological activities and chemical substances.

http://dx.doi.org/10.21577/0100-4042.20250120

Publicado online: abril 3, 2025
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Artigo Quim. Nova 2025, 48(), e-20250134, 1-8

 

Phytochemical study from the aerial parts of Pavonia malacophylla (Malvaceae) and evaluation of its antimicrobial potential

Janderson Barbosa Leite de AlbuquerqueI; Otemberg Souza ChavesI; Wallace Amorim Machado de QueirozI;
Bárbara Fernandes Araújo RodriguesII; Diégina Araújo FernandesIII; Fábio Correia SampaioIV; Maria de Fátima AgraV; Maria de Fátima Vanderlei de SouzaI,II,*


A phytochemical investigation of the aerial parts of Pavonia malacophylla resulted in the isolation and identification of eighteen compounds, revealing antimicrobial potential in its extract, fractions and isolated compounds.

http://dx.doi.org/10.21577/0100-4042.20250134

Publicado online: maio 5, 2025
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Quim. Nova 2025, 48(), e-20250137, 1-7

 

A new alkaloid isolated from Tabernaemontana hystrix Steud. (Apocynaceae) and the antiproliferative potential of the root bark against human cervical cancer (HeLa)

Thalya S. R. NogueiraI,*; Thiago C. SardouII; Julio Cesar Thurler JúniorII; Gabriela DinisIII; Vinícius D'avila B. PascoalII;
Lucas S. AbreuIII; Raimundo Braz FilhoI,IV; Aislan C. R. F. PascoalII; Ivo José C. VieiraI


Tabernaemontana hystrix (Apocynaceae) root bark showed antiproliferative potential against the HeLa cell line. Six alkaloids were isolated from EtOAc or BuOH fractions. Compounds 3 and 4 are being reported for the first time in the species, and compound 6 is new in the literature.

http://dx.doi.org/10.21577/0100-4042.20250137

Publicado online: maio 6, 2025
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Quim. Nova 2025, 48(), e-20250138, 1-8

 

Fragmentation of deprotonated plumeran indole alkaloids by electrospray ionization tandem mass spectrometry

Yan R. RoblesI; Ricardo VessecchiI; Ivo J. C. VieiraII; Raimundo Braz-FilhoII,III,#; Antonio E. M. CrottiI,*


The fragmentation of deprotonated aspidospermine, aspidocarpine, demethoxypalosine, and aspidolimine was investigated in this work using negative electrospray ionization tandem mass spectrometry.

http://dx.doi.org/10.21577/0100-4042.20250138

Publicado online: maio 9, 2025
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Quim. Nova 2025, 48(), e-20250139, 1-8

 

Chemical composition, antioxidant potential, and cholinesterase inhibitory activity of essential oils from three Thunbergia species growing wild in northeast Brazil

Alice M. S. de Almeida; Tchiara M. A. Tenório; Lucas V. B. Rodrigues; Carolina A. de Araujo; Claudio A. G. da Camara*;
Marcilio M. de Moraes


The analysis of essential oils from three Thunbergia species revealed differences in their chemical profiles, but all contained sesquiterpenes as the predominant compounds. The oil from T. erecta demonstrated the highest efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid), AChE (acetylcholinesterase), and BuChE (butyrylcholinesterase) assays.

http://dx.doi.org/10.21577/0100-4042.20250139

Publicado online: maio 9, 2025
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Quim. Nova 2025, 48(), e-20250140, 1-6

 

Chemical constituents from the leaves of Eriodictyon californicum (Hook. & Arn.) Torr. (Boraginaceae)

Brenda K. M. SousaI; Talita L. N. GonçalvesI; Lívia M. DutraI; Victória L. A. SantosII; Emmanoel Vilaça CostaIII;
Agnaldo R. M. ChavesIV, José M. PintoIV, Marcelo F. R. SilvaV; Yuri M. NascimentoV; Josean F. TavaresV; Marcelo S. SilvaV;
Jackson R. G. S. AlmeidaI,*


Seven compounds, belonging to the flavonoid, phenylpropanoid and chromone classes, were isolated from the leaves of Eriodictyon californicum. Among the isolated compounds, ethyl cinnamate (6) and 5-hydroxy-7-methoxychromone (7) are being reported for the first time in E. californicum and in the Boraginaceae family.

http://dx.doi.org/10.21577/0100-4042.20250140

Publicado online: maio 12, 2025
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Quim. Nova 2025, 48(), e-20250145, 1-4

 

Fenilpropanoides com ação anti-Trypanosoma cruzi isolados das folhas de Piper crassinervium (Piperaceae)

Nathalia F. QuintilianoI,II; Sávio R. SoaresII; Miriam UemiI; Guilherme M. AntarIII; Patricia SartorelliII; Andre G. TemponeIV;
João Henrique G. LagoI,*


Bioactive hexane extract from leaves of Piper crassinervium was subjected to a bioactivity-guided fractionation to afford five metabolites (1-5). Compound 5 is previously undescribed while compounds 1, 2 and 4 are being described for the first time in P. crassinervium. Compounds 1-5 were evaluated against trypomastigote forms of parasite Trypanosoma cruzi whereas their toxicity was evaluated against NCTC cells.

http://dx.doi.org/10.21577/0100-4042.20250145

Publicado online: maio 21, 2025
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Quim. Nova 2025, 48(), e-20250146, 1-4

 

Hirtinol A: a new limonoid from the seeds of Trichilia hirta Linneaus (Meliaceae)

Renata Rodrigues da Silva RobainaI,*; Gabriela DinisII; Lucas Silva AbreuII; Raimundo Braz-FilhoI,III; Ivo José Curcino VieiraI


The phytochemical study of Trichilia hirta Linneaus (Meliaceae) seeds resulted in the isolation and identification of a new limonoid named Hirtinol A, in addition to a mixture of 21α-melianone and 21β-melianone, and the glycoside schumaniofioside A.

http://dx.doi.org/10.21577/0100-4042.20250146

Publicado online: maio 21, 2025
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Quim. Nova 2025, 48(), e-20250147, 1-5

 

Stereoselective oxidative coupling of methyl trans-ferulate to (±)-trans-dehydrodiferulate dimethyl ester by Trametes versicolor FC: an enantioselective green approach

Eliane O. SilvaI,*; Herbert J. DiasII,III; Anderson R. M. OliveiraIII; Antônio E. M. CrottiIII


Methyl trans-ferulate was converted into the dihydrobenzofuran neolignan trans-dehydroferulate dimethyl ester with good enantioselectivity using an advantageous approach based on Trametes versicolor FC.

http://dx.doi.org/10.21577/0100-4042.20250147

Publicado online: maio 30, 2025
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Quim. Nova 2025, 48(), e-20250149, 1-7

 

Regioselective and chemoselective biocatalytic reduction of α,β,γ,δ-unsaturated ketones by marine-derived fungus Penicillium citrinum CBMAI 1186

Pedro H. DamadaI,*; Pedro H. O. SantiagoII; Javier EllenaII; André L. M. PortoI


The graphic shows Penicillium citrinum CBMAI 1186 reducing α,β-unsaturated ketones to γ,δ-unsaturated ketones at 32 ºC and 135 rpm. This demonstrates the regioselective and chemoselective efficiency of the strain, highlighting its potential as a biocatalyst.

http://dx.doi.org/10.21577/0100-4042.20250149

Publicado online: junho 3, 2025
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Quim. Nova 2025, 48(), e-20250151, 1-6

 

Glicosídeos esteroidais de Solanum jabrense Agra & M.Nee

Anauara Lima e SilvaI; Thiago A. M. BritoI; Maria de Fátima AgraII; Marcelo S. da SilvaI; Josean F. TavaresI,*


Saponins and glycosylated steroidal alkaloids were isolated from the hydroalcoholic extract of aerial parts of Solanum jabrense Agra & M.Nee, identified and characterized by nuclear magnetic resonance (NMR), infrared spectroscopy (IR), mass spectrometry (MS) and optical rotation.

http://dx.doi.org/10.21577/0100-4042.20250151

Publicado online: junho 10, 2025
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Quim. Nova 2025, 48(), e-20250153, 1-5

 

Antimicrobial activity of compounds isolated from mangrove-derived endophytic fungus Actinomucor elegan against Xanthomonas axonopodis pv. passiflorae

Kathia Raquel Murillo PadillaI; Rayanne Priscila Vieira da ConceiçãoI; Gisele da Costa RamosI; Luana Cardoso de OliveiraII,
José Edson de Sousa SiqueiraI; Mayra Suelen da Silva PinheiroIII; Patrícia Santana Barbosa MarinhoI,;
Andrey Moacir do Rosario MarinhoI,II,*


Tyrosol derivative compounds isolated from Actinomucor elegan fungus show good antimicrobial activity against  Xanthomonas bacteria which causes bacterial spots in passion fruit.

http://dx.doi.org/10.21577/0100-4042.20250153

Publicado online: junho 10, 2025
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Quim. Nova 2025, 48(), e-20250154, 1-9

 

1-Indanone derivatives: a novel one-pot approach to imides via beckmann-like rearrangement and theoretical insights into their interactions with ache enzyme

Thiago R. F. BastosI; Telma Leda G. de LemosI; Raimundo Braz FilhoII,III; Aluísio Marques da FonsecaIV;
Francisco J. Queiroz MonteI,*


Novel imides were synthesized from (E)-2,3-dihydro-1H-inden-1-one oxime via Beckmann-like rearrangement with nucleophilic catalysts. Molecular docking indicated that derivatives 5i, 5g, and 5h showed promising acetylcholinesterase inhibition compared to galantamine.

http://dx.doi.org/10.21577/0100-4042.20250154

Publicado online: junho 11, 2025
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Quim. Nova 2025, 48(), e-20250158, 1-5

 

PELTOGYNOIDS FROM Peltogyne catingae DUCKE AND THEIR ANTIFUNGAL POTENTIAL AGAINST Sporothrix spp.

Davi S. Oliveira; Priscila B. A. de Souza; Luiz Henrique K. Queiroz-Junior; Denise O. Scoaris; Luana P. da Silva;
Claudete C. do Nascimento; Maria da Paz Lima


The modified flavonoids known as peltogynoids extracted from the wood residues of Peltogyne catingae Ducke ("roxinho") presented antifungal properties against Sporothrix schenckii and S. brasiliensis that cause feline sporotrichosis.

http://dx.doi.org/10.21577/0100-4042.20250158

Publicado online: junho 16, 2025
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Quim. Nova 2025, 48(), e-20250159, 1-6

 

LC-MS/MS BASED DEREPLICATION OF ISOQUINOLINE-DERIVED ALKALOIDS FROM THE TRUNK BARK OF Unonopsis rufescens (Baill.) R.E.Fr. (Annonaceae)

Lucas Antônio F. de Almeida; Felipe Moura A. da Silva ; Bruna Ribeiro de Lima; Aline Bastos B. de Sousa;
Francinaldo A. da Silva Filho; Brenda R. C. Leocadio ; Ana Paula A. Castro; Rebeca dos S. França; Hector H. F. Koolen ;
Afonso D. L. de Souza; Maria Lúcia B. Pinheiro


Pallidine and other isoquinoline-derived alkaloids were tentatively identified in the trunk bark of U. rufescens through liquid chromatography coupled to tandem mass spectrometry analysis (LC-MS/MS) and fragmentation pattern analysis.

http://dx.doi.org/10.21577/0100-4042.20250159

Publicado online: junho 17, 2025
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Nota Técnica Quim. Nova 2025, 48(), e-20250160, 1-5

 

COLLISION-INDUCED DISSOCIATION IN ESI-MS/MS OF CARAMBOXIN ISOLATED FROM Averrhoa carambola: COMPUTATIONAL AND MASS SPECTROMETRY STUDIES

Ricardo Vessecchi ; Pâmela R. R. Pereira; Leonardo Gobbo-Neto; Norberto Garcia-Cairasco; Norberto Peporine Lopes


Fragmentation from electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of caramboxin, a natural toxin, was explored using computational chemistry.

http://dx.doi.org/10.21577/0100-4042.20250160

Publicado online: junho 17, 2025
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Artigo Quim. Nova 2025, 48(), e-20250162, 1-7

 

AMIDES ISOLATED FROM THE LEAVES OF Piper tuberculatum Jacq. (Piperaceae) WITH ACETYLCHOLINESTERASE INHIBITION AND LARVICIDAL ACTIVITY AGAINST Aedes aegypti

Brenda R. C. Leocadio ; Taynara S. Vale; Felipe M. A. da Silva ; João V. C. O. Santos; Sergio M. Nunomura ; André C. de Oliveira; Ingrity S. C. Sá; Rosemary A. Roque; Ana Paula A. Castro; Magno P. Muniz ; Rita C. S. Nunomura


cis-Piplartine, piplartine and 4,5-dihydropiperlongumine isolated from leaves of Piper tuberculatum were active against Aedes aegypti larvae and have acetylcholinesterase (AChE) inhibitory activity.

http://dx.doi.org/10.21577/0100-4042.20250162

Publicado online: junho 17, 2025
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Quim. Nova 2025, 48(), e-20250165, 1-5

 

Bixa orellana LIPIDS AS A SOURCE OF GERANYLGERANIOL: EXTRACTION TECHNIQUES AND CHARACTERIZATION

Miguel A. Martinez Gutierrez ; Igor F. P. da Silva; Henrique F. Goulart; Antônio E. G. Santana


Obtaining oil from urucum seeds by ultrasound-assisted extraction, Soxhlet, and steam distillation methods, characterization, and quantification.

http://dx.doi.org/10.21577/0100-4042.20250165

Publicado online: junho 25, 2025
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Quim. Nova 2025, 48(), e-20250164, 1-6

 

A NEW PRENYLATED GUAIANE FROM THE BROWN SEAWEED Dictyota mertensii

Neilyane de Paula Fernandes; Fábio do Nascimento Ávila ; Késya Amanda D. Rocha ; Pedro B. de Mâcedo Carneiro ;
Greyce L. Sasahara ; Flavia A. Santos ; Edilberto R. Silveira ; Otília Deusdenia L. Pessoa


The chemical investigation of the ethyl acetate extract from the brown seaweed Dictyota mertensii led to the isolation of prenylated guaiane and dolabellane diterpenes.

http://dx.doi.org/10.21577/0100-4042.20250164

Publicado online: junho 25, 2025
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On-line version ISSN 1678-7064 Printed version ISSN 0100-4042
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