JBCS

A phytochemical investigation of the aerial parts of Pavonia malacophylla resulted in the isolation and identification of eighteen compounds, revealing antimicrobial potential in its extract, fractions and isolated compounds.

Tabernaemontana hystrix (Apocynaceae) root bark showed antiproliferative potential against the HeLa cell line. Six alkaloids were isolated from EtOAc or BuOH fractions. Compounds 3 and 4 are being reported for the first time in the species, and compound 6 is new in the literature.

The fragmentation of deprotonated aspidospermine, aspidocarpine, demethoxypalosine, and aspidolimine was investigated in this work using negative electrospray ionization tandem mass spectrometry.

The analysis of essential oils from three Thunbergia species revealed differences in their chemical profiles, but all contained sesquiterpenes as the predominant compounds. The oil from T. erecta demonstrated the highest efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid), AChE (acetylcholinesterase), and BuChE (butyrylcholinesterase) assays.

Seven compounds, belonging to the flavonoid, phenylpropanoid and chromone classes, were isolated from the leaves of Eriodictyon californicum. Among the isolated compounds, ethyl cinnamate (6) and 5-hydroxy-7-methoxychromone (7) are being reported for the first time in E. californicum and in the Boraginaceae family.

Bioactive hexane extract from leaves of Piper crassinervium was subjected to a bioactivity-guided fractionation to afford five metabolites (1-5). Compound 5 is previously undescribed while compounds 1, 2 and 4 are being described for the first time in P. crassinervium. Compounds 1-5 were evaluated against trypomastigote forms of parasite Trypanosoma cruzi whereas their toxicity was evaluated against NCTC cells.

The phytochemical study of Trichilia hirta Linneaus (Meliaceae) seeds resulted in the isolation and identification of a new limonoid named Hirtinol A, in addition to a mixture of 21α-melianone and 21β-melianone, and the glycoside schumaniofioside A.

Methyl trans-ferulate was converted into the dihydrobenzofuran neolignan trans-dehydroferulate dimethyl ester with good enantioselectivity using an advantageous approach based on Trametes versicolor FC.

The graphic shows Penicillium citrinum CBMAI 1186 reducing α,β-unsaturated ketones to γ,δ-unsaturated ketones at 32 ºC and 135 rpm. This demonstrates the regioselective and chemoselective efficiency of the strain, highlighting its potential as a biocatalyst.

Saponins and glycosylated steroidal alkaloids were isolated from the hydroalcoholic extract of aerial parts of Solanum jabrense Agra & M.Nee, identified and characterized by nuclear magnetic resonance (NMR), infrared spectroscopy (IR), mass spectrometry (MS) and optical rotation.

Tyrosol derivative compounds isolated from Actinomucor elegan fungus show good antimicrobial activity against  Xanthomonas bacteria which causes bacterial spots in passion fruit.

Novel imides were synthesized from (E)-2,3-dihydro-1H-inden-1-one oxime via Beckmann-like rearrangement with nucleophilic catalysts. Molecular docking indicated that derivatives 5i, 5g, and 5h showed promising acetylcholinesterase inhibition compared to galantamine.

The modified flavonoids known as peltogynoids extracted from the wood residues of Peltogyne catingae Ducke ("roxinho") presented antifungal properties against Sporothrix schenckii and S. brasiliensis that cause feline sporotrichosis.

Pallidine and other isoquinoline-derived alkaloids were tentatively identified in the trunk bark of U. rufescens through liquid chromatography coupled to tandem mass spectrometry analysis (LC-MS/MS) and fragmentation pattern analysis.

cis-Piplartine, piplartine and 4,5-dihydropiperlongumine isolated from leaves of Piper tuberculatum were active against Aedes aegypti larvae and have acetylcholinesterase (AChE) inhibitory activity.

The chemical investigation of the ethyl acetate extract from the brown seaweed Dictyota mertensii led to the isolation of prenylated guaiane and dolabellane diterpenes.

Obtaining oil from urucum seeds by ultrasound-assisted extraction, Soxhlet, and steam distillation methods, characterization, and quantification.

The graphical abstract shows a diagram linking Eugenia uniflora L. leaf extracts, antioxidant activity, and analytical techniques (total phenolic content (TPC), total flavonoid content (TFC), gas chromatography-mass spectrometry (GC-MS), and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS)) used in this study as well as the molecular structures of the compounds found in this species.

Optimization of extraction of phenolic compounds from Lippia alba (Mill.) N. E. Brown leaves by ultrasound and comparison with conventional techniques.

The metabolic fingerprinting of Palythoa caribaeorum, Palythoa variabilis and Zoanthus spp. collected at different Brazilian oceanic islands showed core species-specific metabolites similar to those of continental zoantharians, and a dynamic fraction of an environment-driven chemodiversity.

The genera of the Myristicaceae family that have special mixed pathway metabolites are Horsfieldia, Iryanthera, Knema, Myristica, Pycnanthus and Virola.

Five substances belonging to the terpenoid class were isolated from the roots of Annona vepretorum Mart. The five substances are characterized by the presence of the kaurene and kaurane diterpenes skeleton. The compound 17-nor-kaur-16-one (2) is being reported for the first time in the Annonaceae family.

Extraction, isolation and detection of haemanthidine in the Crinum scabrum leaves.

This study investigates N-derivatives of friedelan-3-one from Maytenus gonoclada, employing the NEQUIM Active-IT bioactivity prediction tool and experimentally validating their in vitro activity against Leishmania amazonensis, thereby revealing potential therapeutic applications.

The graphical abstract depicts the solvent extraction of Cattleya nobilior to evaluate cytotoxic and anti-Trypanosoma cruzi activities. Metabolomics analysis linked chemical composition to bioactivity, revealing promising pharmacological potential.

A diagram linking the molecular networking of extracts from Senna multijuga obtained from Global Natural Product Social Molecular Networking (GNPS) platform and the antioxidant and tripanocidal potential of this species is presented in this Graphical Abstract.

Amapa latex is a traditional medicine in the Amazon and is commercialized from two plant species Parahancornia amapa and Brosimum parinarioides. We report the isolation of the main compounds from both species and compared the chromatographic profiles by high-performance liquid chromatography (HPLC).

Biotransformation of cafestol isolated from green coffee beans by fermentation with commercial yeasts (Saccharomyces cerevisiae).

Main databases used to search for articles about Remijia, and some of their biological activities and chemical substances.

Omics approaches have revolutionized natural products research, and are widely applied in the identification of biosynthetic pathways, new bioactive compounds, and biomarkers. This review aims to contextualize the main omics techniques, providing new perspectives for future studies in this field.

This review examines the efforts of the Brazilian scientific community in exploring new natural products to combat tuberculosis, a crucial initiative given Brazil's vast biodiversity and substantial tuberculosis burden.

Fragmentation from electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of caramboxin, a natural toxin, was explored using computational chemistry.

The effects of nitroso and fluorine groups in electrophilic aromatic substitution lack consensus across literature and textbooks. Beneath this apparent inconsistency lies a deeper layer of inherent details governing their effects on reactivity, which we unveil in this study.